Researchers discover previously unknown cellular defect in Parkinson’s disease

first_img“Idiopathic or genetic dysfunction of calcium signaling triggers a sequence of pathological events leading to autophagic dysfunction, progressive loss of dopaminergic neurons and age-dependent impairment of vital motor functions typical for Parkinson’s disease,” explained corresponding author Victoria Bolotina, PhD, professor of medicine at BUSM.“Discovery of this new mechanism associated with human Parkinson’s disease and our ability to mimic this pathology in a novel genetic model opens new opportunities for finding a cure for this devastating neurodegenerative disease,” she added. Email A team of local researchers have discovered a previously unknown cellular defect in patients with idiopathic Parkinson’s disease, and identified a sequence of pathological events that can trigger or accelerate premature death of certain neurons in the brain seen in this disease.The findings, published in the journal Nature Communications, will provide a better understanding and further research towards a possible cure of Parkinson’s disease, which is a neurodegenerative disorder that affects movement and other vital functions in nearly one million people in the United States. Despite advances in understanding the causes of familial forms of this disease, the most prevalent idiopathic form of Parkinson’s disease remains a mystery.Boston University School of Medicine (BUSM) researchers discovered that the cells of people with idiopathic Parkinson’s disease have a previously unknown defect in the function of a specific PLA2g6 protein, causing dysfunction of calcium homeostasis that can determine whether some cells will live or die. Pinterest Sharecenter_img Share on Facebook Share on Twitter LinkedInlast_img read more

Key Trump surrogates once led fight vs. WikiLeaks and Assange

first_imgKey Trump surrogates once led fight vs. WikiLeaks and Assange Author: CBS News Do you see a typo or an error? Let us know. (CBS) — President-elect Trump cast doubt on Twitter Wednesday about the U.S. intelligence community’s assessment that Russia was behind the hacking of Hillary Clinton’s presidential campaign and the Democratic National Committee. In doing so, Mr. Trump appeared to side with WikiLeaks founder Julian Assange, who asserts Russia didn’t give his group the hacked Democratic emails that shook up the 2016 election.But back in 2010, when WikiLeaks first came to prominence after the massive leak by Army intelligence analyst Chelsea Manning, several people who are now notable Trump surrogates led the charge against the organization and its controversial leader. They called Assange, among other things, a “handmaiden of terror” and “enemy combatant” with “blood on his hands.”Those surrogates include Rep. Peter King, of New York, a member of the House Permanent Select Committee on Intelligence, former CIA Director James Woolsey, former House Speaker Newt Gingrich, and former Alaska Governor and Republican vice presidential candidate Sarah Palin. Even Mr. Trump himself weighed in on Assange in 2010, saying, “I think it’s disgraceful. I think there should be like death penalty or something,” in video uncovered by shown on CNN’s KFile on Wednesday.“This person should be pursued,” King declared in a November 2010 Fox News interview. “Assange is absolutely guilty. He does have blood on his hands. And the fact is that there should be much more outrage.”“They are aiding and abetting terrorist organizations. They are providing the weapons to terrorist organizations, giving them information which they can use to kill Americans,” King said of WikiLeaks, adding, “Because they are accessories to a terrorist organization, we should declare them a terrorist organization.”In December that same year, Rep. King introduced a bill targeting WikiLeaks.“I consider Mr. Assange a handmaiden of terror. And he definitely has blood on his hands as far as I’m concerned,” said former CIA Director James Woolsey, now a Trump national security adviser and media surrogate, in a November 2010 MSNBC interview.Contrast that to his response Wednesday when asked about Mr. Trump’s citing of Julian Assange. “I don’t know what Julian Assange knows,” Woolsey said. “This really ought to be a situation in which we get at the facts and understand them before we start making judgments, it seems to me.” Another vocal Trump surrogate, Gingrich, commented on the issue seven years ago. “Information warfare is warfare, and Julian Assange is engaged in warfare. Information terrorism, which leads to people getting killed, is terrorism, and Julian Assange is engaged in terrorism,” he said in a December 2010 Fox interview. He concluded that Assange “should be treated as an enemy combatant. WikiLeaks should be closed down permanently and decisively.”Palin once condemned Assange in 2010 as an “anti-American operative with blood on his hands” after WikiLeaks published leaked emails of hers.But she did a complete 180 Tuesday, telling Assange she’s sorry, tweeting,”To Julian Assange: I apologize.”Elaborating in a Facebook post, Palin wrote, “I apologize for condemning Assange when he published my infamous (and proven noncontroversial, relatively boring) emails years ago,” and thanked him for exposing Democrats.center_img Published: January 5, 2017 5:19 AM EST Updated: January 5, 2017 5:21 AM EST SHARElast_img read more

Court grants Nigeria more time to appeal $10 billion gas project…

first_imgU.N. doubles aid appeal for northeastern Nigeria to $1 billion MOSCOW, RUSSIA – AUGUST 30, 2019: A gavel at an auction of 34 old light box signs recently removed from Moscow Underground (Moscow Metro) stations; the auction took place at Vystavochnaya Station. Vladimir Gerdo/TASS (Photo by Vladimir GerdoTASS via Getty Images) A gavel. Nigeria has been granted more time to appeal against a penalty in relation to a botched gas project. (Photo by Vladimir GerdoTASS via Getty Images)Nigeria won a temporary reprieve after a court in London granted it more time to appeal against a multi-billion dollar penalty in a case lodged by a UK-based company, Process Industrial and Developments (P&ID).The court ruled that Nigeria can now lodge its appeal but it did not set any definite time frame.P&ID sued Nigeria in 2012 after a deal to develop a gas-processing plant, which it was awarded, collapsed.P&ID, which was set up solely for the project, argued it spent $40 million on design and feasibility but never built the plant as the government did not honour its obligation to supply the gas it was meant to process.Three years ago, P&ID was awarded $6.6 billion, plus interest, based on what it could have earned over the course of 20 years.The daily interest of $1.2 million was backdated from 2013 meaning the award now stands at nearly $10 billion.Last September, Nigeria was given permission by a British judge to seek to have that ruling dismissed. It, however, missed the original appeal deadline.The West African nation’s Minister for Justice, Abubakar Malami, told the BBC that the country will continue its pursuit of the case until the ruling against it is dismissed.Related Nigeria’s Court of Appeal jails foreign nationals for oil theftcenter_img Nigeria announces $5.8 billion deal for record-breaking power projectlast_img read more